ELTE TTK Eötvös terem (0.83)
October 04, 2014 09:00AM
To October 04, 2014 01:00PM
Chair by Dr András Perczel, chairman of the board
Dr. László Lovász chair, Hungarian Academy of Sciences
Dr. József Pálinkás, Government Commissioner for Research
Dr. Zsolt Frei Vice-Rector, Eötvös Loránd University
Dr. Márta Fülöp social psychologist, MTA TTK – ELTE PPK
Dr. István Greiner, chemical engineer, Richter Gedeon Zrt
During the last ten years significance of protein drugs increased enormously. A domestic company here, in Mid-Eastern Europe made a brave decision with entering into this field where most advanced technologies are needed and where giant competitors are present. The activity involves establishment, development and production of protein drugs. The presentation will allow to feel the taste and flavour of resources implemented into this process.
10.40 – 11.00 Coffee break
Dr. András Perczel, biochemist, Eötvös Loránd University
Andrea Bodor – Lajos Kalmár – László Nyitray – Gábor Pál
By stimulating migration and invasive phenotype of cells and by modulating programmed cell-death (apoptosis), the S100A4 protein (also called metastasin) is an important player in tumor metastasis and chronic inflammation. S100A4 exerts its migration and invasion related function through binding to the non-muscle myosin 2A (NM2A) motor protein, while it exerts its apoptosis modulating function through binding to the p53 tumor suppressor protein. Our academic and treatment oriented research project is initiated and performed by scientists from three institutions (the Biology and Chemistry Institutes of Eötvös University as well as the Institute of Enzymology of Hungarian Academy of Sciences) and aims to decipher the molecular details of formation and stability of the above mentioned protein complexes based on a combination of biophysical measurements, structural bioinformatics, NMR spectroscopy and directed protein evolution.
Edit Búzás – Mihály Józsi
Cell-derived extracellular vesicles play an important role in inflammatory processes; after reaching the circulation and the interstitial space they may interact with an other important factor of innate immunity, the complement system.
The goal of the project is to explore how the complement system is activated upon interaction with different cell derived extracellular vesicles. Furthermore, the current project aims investigating how the interaction with activated complement affects the binding of extracellular vesicles to cells and how cell activation performes.
László Cervenak – Péter Gál – Gábor Pál
Inflammatory disorders are severe disease conditions and in most cases there is no adequate and specific treatment available, since the exact pathomechanisms of the inflammatory reactions and the related potential drug targets are unknown. In the frame of the Synergy Program three research groups (structural biophysics group of the Research Center for Natural Sciences (RCNS), 3rd Department of Internal Medicine, Semmelweis University, and Department of Biochemistry, Eötvös University) join their forces in order to reveal the details of a newly discovered mechanism for initiation inflammation. They study the direct cell-stimulation effect of the serine protease enzymes of the innate immune system on endothelial cells and leukocytes, as well as, they develop efficient inhibitors to prevent pathological cell activation.
Attila Bóta – György Marosi
The macromolecular biopharmaceuticals are extremely sensitive to environmental influences. Thus the aim of our cooperation is the preparation of such carrier nanostructures that ensure the stability of physical-chemical structure much better than the liquid parenteral formulations. Furthermore for ensuring the reliability of the technologies, chemometry-aided real time spectroscopic methods and small angle x-ray methods will be developed.
László Buday – László Nyitray – Beáta Vértessy
The role of signal transduction proteins in carcinogenesis have been long recognized, and numerous examples are covered in details in the literature. Our collaboration aims revealing the mechanistic secrets of molecular events in specific focused cases. The complexes covered in our joint project are involved in signal transduction, DNA damage repair, carcinogenesis and metastasis.
Péter Fürjes – Krisztián Papp
The specific aim of our cooperation is the development of a complex autonomous microfluid device and implementation of an immunological process that can be suitable for the measurement and activation of neutrophil granulocytes playing central role in inflammation. The proposed teamwork combines engineering and material processing with biological knowledge: the working group of HAS - Research Center for Natural Sciences - provides the micromachining and microfluidic background, while the MTA-ELTE Immunology Research Group contributes immunological expertise to the cooperation. Innovative application and the high tech micro and biotechnology devices, emerging from conventional material structures develope such a complex Lab-on-a-chip system, which integrates the sensing and sample preparation possibilities.
Gábor Bánhegyi – Csaba Sőti – Tibor Vellai
Despite its high medical, social and economic significance, the biological basis of ageing remains largely unknown. In the frame of this collaboration, we intend to uncover genetic factors and proteins that actually cause ageing. We also wish to determine the functional interactions between proteins known to influence the rate of the ageing process (i.e., lifespan). Our potential results may lead to a better understanding of the molecular mechanisms underlaying the incidence of various age-related diseases.