March 08, 2017 12:00AM
To March 08, 2017 12:00PM
March 8. 2017. 4 p.m. MTA TTK Kisterem
Muscular movement plays an essential role not only in our lives. Muscle contraction is initiated by the release of calcium from the sarcoplasmic reticulum into the cytoplasm of myocytes through ryanodine receptors. Calcium binds to troponin, which releases tropomyosin from its blocking position allowing myosin filaments to move along actin filaments resulting in the contraction of the muscle. In my talk I will present not only our recent cryo-EM structure of a human cytoplasmic actomyosin complex, but also high-resolution structures of the mouse ryanodine receptor 1 in its open and closed state and F-actin in complex with tropomyosin. Together, the structures reveal the mechanisms involved in muscle contraction at an unprecedented level of molecular detail.