November 23, 2019 09:00AM
To November 23, 2019 05:00PM
November 23. 2019 at 9:00 am
Venue: ELTE TTK 1117 Budapest, Pázmány Péter sétány 1/a, Eötvös Terem
Lívia Fülöp: A novel target in the drug-design for neurodegenerative diseases: the sigma-1 receptor
As effective therapies against the neurodegenerative diseases are still missing, researchers worldwide now urge investigations of new directions which were to lead to the identification of new mechanisms, whereby an effective therapy could be found against them. A promising target can be the so-called sigma-1 (S1) receptor, which is one of the key-players in the regulation of the endoplasmic reticulum-involved stress-response (ER stress) and calcium-homeostasis. Novel S1-modulators are selected from a molecular library, and tested in different experimental paradigms in order to clarify their effect, hoping that proper agonists would be able to influence ER stress processes in a favorable manner.
Mihály Kovács: Be there on time and do the right thing: novel mechanisms of genome stability
Timely response to DNA damage and resolution of blockades in genome metabolism is crucial for maintaining genome stability, thereby avoiding cell death or cancer. In the presentation I will summarize our recent discoveries on novel genome-protecting mechanisms of DNA metabolic proteins, ranging from DNA structure- and base pair energy-dependent enzymatic processing to liquid-liquid phase separation.
László Virág: The role of protein ADP-ribosylation in the regulation of cell fates
Enzymes of the 17 member PARP family catalyze mono- and poly(ADP-ribosyl)ation of various proteins. MARylation and PARylation can regulate many aspects of a wide array of cell functions (e.g. transcription, chromatin organization, cell cycle, metabolism, autophagy, differentiation and cell death) by altering the physicochemical properties of target proteins, physically interacting with partner proteins and modulating cellular NAD+ content. The lecture will focus on the role of PARylation and nuclear NAD+ synthesis in the regulation of cell death and the functional plasticity of cells.